Exercise alleviates hematopoietic stem cell injury following radiation via the carnosine/Slc15a2-p53 axis.

ABSTRACT: Ionizing radiation (IR) can cause severe dysfunction of hematopoietic stem cells (HSCs), leading to acute or prolonged myelosuppression. In recent years, physical exercise has been recognized as a healthy lifestyle as it can fight a variety of diseases. However, whether it provides protection against IR is not fully understood. In this study, we revealed that long-term moderate exercise mitigated IR-induced hematopoietic injury by generating carnosine from skeletal muscles. We found that exercised mice displayed reduced loss of HSC number and function after IR, accompanied by alleviated bone marrow damage. Interestingly, these effects were largely abrogated by specific deletion of carnosine synthase Carns1 in skeletal muscles. In contrast, carnosine treatment protected HSCs against IR-indu

SUBMITTER: Zeng H 

PROVIDER: S-EPMC11613893 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature