Causal effect of chemotherapy received dose intensity on survival outcome: a retrospective study in osteosarcoma.

ABSTRACT:

Background

This study aims to analyse the effects of reducing Received Dose Intensity (RDI) in chemotherapy treatment for osteosarcoma patients on their survival by using a novel approach. Previous research has highlighted discrepancies between planned and actual RDI, even among patients randomized to the same treatment regimen. To mitigate toxic side effects, treatment adjustments, such as dose reduction or delayed courses, are necessary. Toxicities are therefore risk factors for mortality and predictors of future exposure levels. Toxicity introduces post-assignment confounding when assessing the causal effect of chemotherapy RDI on survival outcomes, a topic of ongoing debate.

Methods

Chemotherapy administration data from BO03 and BO06 Randomized Clinical Trials (RCTs) in

SUBMITTER: Spreafico M 

PROVIDER: S-EPMC11613923 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature