Blockade of Ca_V3 calcium channels and induction of G₀/G₁ cell cycle arrest in colon cancer cells by gossypol.

ABSTRACT:

Background and purpose

Gastrointestinal tumours overexpress voltage-gated calcium (Ca_V3) channels (Ca_V3.1, 3.2 and 3.3). Ca_V3 channels regulate cell growth and apoptosis colorectal cancer. Gossypol, a polyphenolic aldehyde found in the cotton plant, has anti-tumour properties and inhibits Ca_V3 currents. A systematic study was performed on gossypol blocking mechanism on Ca_V3 channels and its potential anticancer effects in colon cancer cells, which express Ca_V3 isoforms.

Experimental approach

Transcripts for Ca_V3 proteins were analysed in gastrointestinal cancers using public repositories and in human colorectal cancer cell lines HCT116, SW480 and SW620. The gossypol blocking mechanism on Ca_V

SUBMITTER: Lopez-Charcas O 

PROVIDER: S-EPMC11613961 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature