Design and synthesis of betulinic acid-dithiocarbamate conjugates as potential antifungal agents against <i>Candida albicans</i>.

ABSTRACT: Diverse betulinic acid-dithiocarbamate conjugates were designed and synthesized via a two-step reaction at room temperature. Among the fourteen dithiocarbamate analogs of betulinic acid, DTC2 demonstrated the best antifungal activity against Candida albicans, with a minimum inhibitory concentration (MIC) of 4 μg mL^-1, achieving 99% fungicidal activity at the same concentration. These compounds were found to be ineffective against common Gram-negative and Gram-positive pathogens, suggesting their specificity to fungi. Furthermore, DTC2 exhibited synergistic effects with the antifungal drugs fluconazole and nystatin, resulting in a significant decrease in MIC by 64 and 16 folds, respectively, when co-administered. Notably, the molecule also hindered hyphae formation

SUBMITTER: Amin H 

PROVIDER: S-EPMC11613976 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature