Inflammation and Microbial Translocation Correlate with Reduced MAIT Cells in People with HIV.

ABSTRACT:

Background

Optimal control of microbial infections requires mucosal-associated invariant T (MAIT) cells. People living with HIV (PWH) on antiretroviral therapy (ART) can be divided into 2 groups: immune responders (IR) who recover or retain CD4 T cell numbers, and immune non-responders (INR) who do not. Compared to IR, INR have fewer MAIT cells and increased systemic inflammation and microbial translocation, but how these factors affect MAIT cells is unknown.

Methods

MAIT cells from IR, INR, and from controls without HIV were enumerated and characterized by flow cytometry. To determine the links among MAIT cells, inflammation, and microbial translocation, the correlations of MAIT cell numbers to previously published soluble inflammatory markers and plasma microbial genetic s

SUBMITTER: Ryu A 

PROVIDER: S-EPMC11613984 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature