Regulation of STING G-quadruplex for rescuing cellular senescence and Aβ phagocytic capacity of microglia.

ABSTRACT: Alzheimer's disease (AD), the most common form of dementia, affects millions of people worldwide and its cause is very complicated. Besides the classical amyloid cascade hypothesis, oxidative stress, metal ion imbalance, cellular senescence and neuroinflammation are also considered crucial triggers of AD. Therefore, therapeutic strategies other than inhibiting Aβ deposition are very promising. As a crucial innate immune pathway, the abnormal activation of the cGAS-STING pathway in AD has attracted much attention and become a promising target for AD treatment. Here, we identify a highly conserved and stable G-quadruplex (G4) in the STING promoter region, and further verify its function in transcriptional inhibition of STING by using CRISPR technology to precisely target STING G4. Intriguing

SUBMITTER: Yuan H 

PROVIDER: S-EPMC11613991 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature