Metabolic modelling links Warburg effect to collagen formation, angiogenesis and inflammation in the tumoral stroma.

ABSTRACT: Cancer cells are known to express the Warburg effect-increased glycolysis and formation of lactic acid even in the presence of oxygen-as well as high glutamine uptake. In tumors, cancer cells are surrounded by collagen, immune cells, and neoangiogenesis. Whether collagen formation, neoangiogenesis, and inflammation in cancer are associated with the Warburg effect needs to be established. Metabolic modelling has proven to be a tool of choice to understand biological reality better and make in silico predictions. Elementary Flux Modes (EFMs) are essential for conducting an unbiased decomposition of a metabolic model into its minimal functional units. EFMs can be investigated using our tool, aspefm, an innovative approach based on logic programming where biological constraints can be incorpor

SUBMITTER: Mahout M 

PROVIDER: S-EPMC11614220 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature