Enhancing bone regeneration and osseointegration using rhPTH(1-34) and dimeric ^R25CPTH(1-34) in an osteoporotic beagle model.

ABSTRACT: This study investigates the effects of two parathyroid hormone (PTH) analogs, rhPTH(1-34) and dimeric ^R25CPTH(1-34), on bone regeneration and osseointegration in a postmenopausal osteoporosis model using beagle dogs. Twelve osteoporotic female beagles were subjected to implant surgeries and assigned to one of three groups: control, rhPTH(1-34), or dimeric ^R25CPTH(1-34). Bone regeneration and osseointegration were evaluated after 10 weeks using micro-computed tomographic (micro-CT), histological analyses, and serum biochemical assays. Results showed that the rhPTH(1-34) group demonstrated superior improvements in bone mineral density, trabecular architecture, and osseointegration compared to controls, while the dimeric ^R25CPTH(1-34) group exhibited similar,

SUBMITTER: Shin JO 

PROVIDER: S-EPMC11614385 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature