Comparison of volumetric brain analysis in subjects with rheumatoid arthritis and ulcerative colitis.

ABSTRACT:

Background

Rheumatoid arthritis (RA) and ulcerative colitis (UC) are two autoimmune diseases where patients report high levels of fatigue, pain, and depression. The effect of systemic inflammation from these diseases is likely affecting the brain, however, it is unknown whether there are measurable neuroanatomical changes and whether these are a contributing factor to these central symptoms.

Methods

We included 258 RA patients with 774 age and sex matched controls and 249 UC patients with 747 age and sex matched controls in a case control study utilizing the UK Biobank dataset. We used imaging derived phenotypes (IDPs) to determine whether there were differences in (1) hippocampal volume and (2) additional subcortical brain volumes between patients compared to controls and i

SUBMITTER: Cox JG 

PROVIDER: S-EPMC11614619 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature