Association between branched-chain amino acid levels and gastric cancer risk: large-scale prospective cohort study.

ABSTRACT:

Background

Gastric cancer (GC) remains a malignancy with high incidence and mortality rates worldwide. Although branched-chain amino acids (BCAAs) play a crucial role in various physiological and pathological processes, their specific relationship with risk of GC remains unclear.

Methods

We conducted a large-scale prospective cohort from UK Biobank database. We evaluated the relationship between BCAA levels and risk of GC using Cox regression, Kaplan-Meier survival curves, the accelerated failure time (AFT) model, and restricted cubic spline (RCS) analysis.

Results

During the follow-up of 12 years, 247,753 participants were included in the study. And the Cox regression analysis revealed that higher levels of isoleucine (HR = 0.65, 95% CI 0.48-0.89; p = 0.007),

SUBMITTER: Yu L 

PROVIDER: S-EPMC11614650 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature