Evaluation of pharmacokinetics and relative bioavailability of pentoxifylline and its metabolite in beagle dogs following different formulations.

ABSTRACT: A single-oral-dose, two-period cross-over study with a 5-day washout period under fed condition was conducted in six beagle dogs to explore the pharmacokinetic characteristics and relative bioavailability between sustained-release (SR) tablets and enteric-coated (EC) tablets of pentoxifylline (PTX) and its metabolite. The results showed that M5 exhibited the highest exposure level, while M1 demonstrated the lowest in both the SR and EC tablet groups. For PTX and M1, T_1/2 were 0.42 and 0.55 h, with t_max of 1.83 and 1.83 h, respectively, in the SR tablet group; in the EC tablet group, T_1/2 were 0.38 and 0.47 h, respectively. However, a significantly prolonged absorption process was noted, with t_max values of 5.06 and 5.78 h. In contrast, M5 exhibit

SUBMITTER: Xu Y 

PROVIDER: S-EPMC11614658 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature