Identification of key genes to predict response to chemoradiotherapy and prognosis in esophageal squamous cell carcinoma.

ABSTRACT:

Background

Chemoradiotherapy is a crucial treatment modality for esophageal squamous cell carcinoma (ESCC). This study aimed to identify chemoradiotherapy sensitivity-related genes and analyze their prognostic value and potential associations with the tumor microenvironment in ESCC.

Methods

Utilizing the Gene Expression Omnibus database, we identified differentially expressed genes between ESCC patients who achieved complete and incomplete pathological responses following chemoradiotherapy. Prognostic genes were then screened, and key genes associated with chemoradiotherapy sensitivity were determined using random survival forest analysis. We examined the relationships between key genes, infiltrating immune cells, and immunoregulatory genes. Additionally, drug sensitivity an

SUBMITTER: Cui Y 

PROVIDER: S-EPMC11614722 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature