Characteristics of putative keystones in the healthy adult human gut microbiota as determined by correlation network analysis.

ABSTRACT: Keystone species are thought to play a critical role in determining the structure and function of microbial communities. As they are important candidates for microbiome-targeted interventions, the identification and characterization of keystones is a pressing research goal. Both empirical as well as computational approaches to identify keystones have been proposed, and in particular correlation network analysis is frequently utilized to interrogate sequencing-based microbiome data. Here, we apply an established method for identifying putative keystone taxa in correlation networks. We develop a robust workflow for network construction and systematically evaluate the effects of taxonomic resolution on network properties and the identification of keystone taxa. We are able to identify correla

SUBMITTER: Bauchinger F 

PROVIDER: S-EPMC11614764 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature