Associations between human milk EV-miRNAs and oligosaccharide concentrations in human milk.

ABSTRACT:

Introduction

Human milk contains human milk oligosaccharides (HMOs) and microRNAs (miRNAs), which are key bioactive components. HMOs are indigestible carbohydrates that impact infant growth and development. miRNAs are small, non-coding RNAs that regulate post-transcriptional gene expression. miRNAs are abundant in human milk and can be contained in extracellular vesicles (EVs). There is evidence that miRNAs are synthesized in the mammary epithelium and may influence mammary gland development and milk synthesis. However, the relationships between miRNAs and HMOs have yet to be fully characterized.

Methods

This study examined the associations between 210 human milk EV-miRNAs and 19 HMOs in a cohort of 98 Latina mothers. HMO measures included summary measures and concentrations

SUBMITTER: Holzhausen EA 

PROVIDER: S-EPMC11614774 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature