Forced MyD88 signaling in microglia impacts the production and survival of regenerated retinal neurons.

ABSTRACT: Inflammation and microglia appear to be key factors influencing the outcome of retinal regeneration following acute retinal damage. Despite such findings, direct connection of microglia-specific inflammatory factors as drivers of regenerative responses in the retina are still not defined, and intracellular pathways activated to stimulate such signals from microglia are currently unknown. We became interested in MyD88 regulation in microglia because transcriptomic datasets suggest myd88 could be regulated temporally in zebrafish microglia responding to damage in the central nervous system. MyD88 is an intracellular molecular adaptor that initiates signaling cascades downstream of several innate immune receptors, and probably most well-known for inducing gene expression of pro-inflamm

SUBMITTER: Rumford JE 

PROVIDER: S-EPMC11614808 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature