Exploring the wound healing potential of dietary nitrate in diabetic rat model.

ABSTRACT:

Introduction

The wound healing in diabetes is hindered and prolonged due to long-term inflammation, oxidative stress damage, and angiogenesis disorders induced by high glucose status. The management of such difficult-to-treat wounds continues to pose a significant challenge in clinical treatment. Dietary nitrate, commonly found in greens such as beets and spinach, acts as a nutritional supplement and is metabolized in the body through the salivary nitrate-nitrite-NO pathway. This pathway plays a crucial role in various physiological functions, including enhancing blood flow and attenuating inflammation.

Methods

In this study, we established a diabetic rat wound model. Forty-eight rats were randomly divided into six groups (n = 8): the Con group, the Con + Nitrate group, the

SUBMITTER: Hu X 

PROVIDER: S-EPMC11614883 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature