Multimodal treatment of glioblastoma with multiple lesions - a multi-center retrospective analysis.

ABSTRACT:

Objective

The presence of multiple localizations (ML) in glioblastoma is rare and associated with perceived poor prognosis. The aim of this study is to evaluate the impact of a multimodal treatment on progression-free survival (PFS) and overall survival (OS) in ML glioblastoma.

Methods

Patients presenting with CNS WHO grade 4 glioblastoma with ML to 2 major German Departments of Neurosurgery between January 1st, 2008, to December 31st, 2020 were included in this study. Primary outcome parameters were extent of resection (EOR) using the 2021 RANO criteria, progression free- and overall survival.

Results

A total of 483 patients with newly diagnosed glioblastoma (CNS WHO grade 4) were assessed. 134 patients presented with ML (72 multifocal (MF), 62 multicentric (MC)). Th

SUBMITTER: Krenzlin H 

PROVIDER: S-EPMC11614972 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature