Response to induction chemotherapy as a prognostic indicator in locally advanced head and neck squamous cell carcinoma.

ABSTRACT:

Purpose

Induction chemotherapy (IC) for patients with locally advanced stage Head and Neck Squamous Cell Carcinomas (HNSCC) before radio-chemotherapy (RCT) or surgery remains a potential treatment option. This study analyzed how the response to IC correlates with survival outcomes.

Methods

We conducted a retrospective single-center study at a tertiary cancer center. Tumors were categorized by anatomical site and response to IC (non-responders vs. responders). Data were analyzed using Kaplan-Meier survival curves and Cox regression analysis.

Results

A total of 48 patients received IC. Of these, 33 patients were radiologically evaluable for response. The majority of evaluable patients received either TPF (Docetaxel, Cisplatin, 5-Fluorouracil) (58%) or TP (Docetaxel, Cis

SUBMITTER: Huwyler F 

PROVIDER: S-EPMC11615028 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature