Comparative study of the three-dimensional genomes of granulosa cells in germinal vesicle and metaphase II follicles.

ABSTRACT:

Introduction

Follicle development is a critical process in the female reproductive system, with significant implications for fertility and reproductive health. Germinal vesicle (GV) oocytes are primary oocytes that are arrested in the dictyate stage, also known as the diplotene stage of meiotic prophase I. Metaphase II (MII) is the stage at which the oocyte is typically retrieved for assisted reproductive technologies such as in vitro fertilization (IVF). The granulosa cells play a pivotal role in follicle development processes. 3D chromatin organization is a fundamental aspect of cellular biology that has significant implications for gene regulation and cellular function.

Methods

In this study, we investigated 3D chromatin organization in granulosacells from GV and M

SUBMITTER: Mao R 

PROVIDER: S-EPMC11615058 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature