Circulating Protein and Metabolite Correlates of Histologically Confirmed Diabetic Kidney Disease.

ABSTRACT:

Rationale & objective

Diabetic kidney disease (DKD) is one of the leading causes of end-stage kidney disease globally. We aim to identify proteomic and metabolomic correlates of histologically confirmed DKD that may improve our understanding of its pathophysiology.

Study design

A cross-sectional study.

Setting & participants

A total of 434 Boston Kidney Biopsy Cohort participants.

Predictors

Histopathological diagnosis of DKD on biopsy.

Outcomes

Proteins and metabolites associated with DKD.

Analytical approach

We performed linear regression to identify circulating proteins and metabolites associated with a histopathological diagnosis of DKD (n = 81) compared with normal or thin basement membrane (n = 27), and other kidney diseases without diabetes

SUBMITTER: Lopez-Silva C 

PROVIDER: S-EPMC11615146 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature