Bioinspired hierarchical porous tough adhesive to promote sealing of high-pressure bleeding.

ABSTRACT: Timely and stable sealing of uncontrolled high-pressure hemorrhage in emergency situations outside surgical units remains a major clinical challenge, contributing to the high mortality rate associated with trauma. The currently widely used hemostatic bioadhesives are ineffective for hemorrhage from major arteries and the heart due to the absence of biologically compatible flexible structures capable of simultaneously ensuring conformal tough adhesion and biomechanical support. Here, inspired by the principle of chromatin assembly, we present a tissue-conformable tough matrix for robust sealing of severe bleeding. This hierarchical matrix is fabricated through a phase separation process, which involves the in-situ formation of nanoporous aggregates within a microporous double-network (DN) m

SUBMITTER: Li Y 

PROVIDER: S-EPMC11615148 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature