Gingival spatial analysis reveals geographic immunological variation in a microbiota-dependent and -independent manner.

ABSTRACT: In mucosal barriers, tissue cells and leukocytes collaborate to form specialized niches that support host-microbiome symbiosis. Understanding the spatial organization of these barriers is crucial for elucidating the mechanisms underlying health and disease. The gingiva, a unique mucosal barrier with significant health implications, exhibits intricate tissue architecture and likely contains specialized immunological regions. Through spatial transcriptomic analysis, this study reveals distinct immunological characteristics between the buccal and palate regions of the murine gingiva, impacting natural alveolar bone loss. The microbiota primarily affects gingival immunity in the buccal region. Additionally, a significant influence of the microbiota on the junctional epithelium facing the oral

SUBMITTER: Jaber Y 

PROVIDER: S-EPMC11615284 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature