High-temperature exposure during the early embryonic stage lowers core body temperature after growth via a hypothalamic Igfbp2-dependent mechanism.

ABSTRACT: The mechanisms underlying individual differences in core body temperature (T_c) are unexplained by genetic factors and poorly understood. Here, we investigated whether the environmental temperature during early development affects postnatal T_c. Mouse embryos were cultured from pronuclear to blastocyst stage in either standard (37 °C) or high (38 °C) temperature, and the T_c of each grown-up adult was measured. The adult 38 °C-incubated mice showed lower T_c than the 37 °C group without changes in activity levels. In the hypothalamus of the 38 °C group, insulin-like growth factor 1 (Igf1) and IGF binding protein 2 (Igfbp2) gene expression increased. The decrease in T_c in the wild-type 38 °C group was alleviated by brain neuron-specific Igf

SUBMITTER: Yoshimura Y 

PROVIDER: S-EPMC11615319 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature