Biodegradable Janus sonozyme with continuous reactive oxygen species regulation for treating infected critical-sized bone defects.

ABSTRACT: Critical-sized bone defects are usually accompanied by bacterial infection leading to inflammation and bone nonunion. However, existing biodegradable materials lack long-term therapeutical effect because of their gradual degradation. Here, a degradable material with continuous ROS modulation is proposed, defined as a sonozyme due to its functions as a sonosensitizer and a nanoenzyme. Before degradation, the sonozyme can exert an effective sonodynamic antimicrobial effect through the dual active sites of MnN₄ and Cu₂O₈. Furthermore, it can promote anti-inflammation by superoxide dismutase- and catalase-like activities. Following degradation, quercetin-metal chelation exhibits a sustaining antioxidant effect through ligand-metal charge transfer, while the rel

SUBMITTER: Ou Z 

PROVIDER: S-EPMC11615367 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature