Causal relationship between inflammatory proteins, immune cells, and gout: a Mendelian randomization study.

ABSTRACT: Prior research has documented the association between certain circulating inflammatory proteins/immune cells and gout. However, the reliability of these associations remains contentious due to the constraints of conventional observational methodologies. This investigation seeks to reassess the causative link between circulating inflammatory proteins/immune cells and gout through the application of Mendelian randomization (MR). The study included 3576 individuals of European ancestry with gout, immune cell data from the GWAS summary of 3757 Sardinians, and circulating inflammatory protein data from 14,824 European ancestry participants for MR analysis. The principal approach employed was inverse variance weighted analysis to investigate the causal relationship between exposure and outcomes.

SUBMITTER: Lai R 

PROVIDER: S-EPMC11615377 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature