Identification and Validation of Serum Biomarkers to Improve Colorectal Cancer Diagnosis.

ABSTRACT:

Background

The pressing need for reliable biomarkers in colorectal cancer (CRC) diagnosis and prognosis is a major global health concern. Current diagnostic methods rely heavily on invasive procedures like colonoscopy, and existing biomarkers such as Carbohydrate Antigen 19-9 (CA19-9) and Carcinoembryonic Antigen (CEA) exhibit limitations in accuracy and specificity.

Aims

This study aims to identify and validate novel biomarkers that can enhance the early detection and diagnostic precision of CRC while overcoming the shortcomings of conventional biomarkers.

Materials and methods

Leveraging advancements in genomic and proteomic technologies, gene expression datasets were obtained from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA). We identified d

SUBMITTER: Yoon ML 

PROVIDER: S-EPMC11615507 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature