Black Phosphorus Nanosheets-Loaded Mussel-Inspired Hydrogel with Wet Adhesion, Photothermal Antimicrobial, and In Situ Remineralization Capabilities for Caries Prevention.

ABSTRACT: The main features of early caries are the massive colonization of cariogenic bacteria and demineralization of tooth enamel by the acids that they produce. Owing to the lack of effective treatments, the development of anticaries therapeutics with both antimicrobial and remineralizing properties is urgently required. Black phosphorus nanosheets (BPNs) are ideal therapeutics for the treatment of early caries because they can mediate photothermal antibacterial activity and subsequently promote remineralization by generating PO₄ ^3-. However, the dynamic and wet environment of the oral cavity prevents the long-term adhesion of BPNs to the tooth surface. In this study, using catechol-modified chitosan and PLGA-PEG-PLGA as raw materials, a mussel-inspired versatile hydrogel,

SUBMITTER: Ran Y 

PROVIDER: S-EPMC11615761 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature