Proteomics and Incident Kidney Failure in Individuals With CKD: The African American Study of Kidney Disease and Hypertension and the Boston Kidney Biopsy Cohort.

ABSTRACT:

Rationale & objective

Individuals with chronic kidney disease (CKD) are at increased risk of morbidity and mortality, particularly as they progress to kidney failure. Identifying circulating proteins that underlie kidney failure development may guide the discovery of new targets for intervention.

Study design

Prospective cohort.

Setting & participants

703 African American Study of Kidney Disease and Hypertension (AASK) and 434 Boston Kidney Biopsy Cohort (BKBC) participants with baseline proteomics data.

Exposures

Circulating proteins measured using SomaScan.

Outcomes

Kidney failure, defined as dialysis initiation or kidney transplantation.

Analytical approach

Using adjusted Cox models, we studied associations of 6,284 circulating proteins with ki

SUBMITTER: Chen TK 

PROVIDER: S-EPMC11615895 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature