Preclinical validation and kinetic modelling of the SV2A PET ligand [¹⁸F]UCB-J in mice.

ABSTRACT: Synaptic vesicle protein 2A (SV2A) is ubiquitously expressed in presynaptic terminals where it functions as a neurotransmission regulator protein. Synaptopathy has been reported during healthy ageing and in a variety of neurodegenerative diseases. Positron emission tomography (PET) imaging of SV2A can be used to evaluate synaptic density. The PET ligand [¹¹C]UCB-J has high binding affinity and selectivity for SV2A but has a short physical half-life due to the ¹¹C isotope. Here we report the characterization and validation of its ¹⁸F-labeled equivalent, [¹⁸F]UCB-J, in terms of specificity, reproducibility and stability in C57BL/6J mice. Plasma analysis revealed at least one polar radiometabolite. Kinetic modelling was performed using a population-

SUBMITTER: Everix L 

PROVIDER: S-EPMC11615906 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature