New Insights on the Burst Release Kinetics of Spray-Dried PLGA Microspheres.

ABSTRACT: Spray drying is one of the leading manufacturing methods for active pharmaceutical ingredients (APIs) owing to its rapid, single-step, and cost-effective nature. It also has the capacity to generate microspheres capable of controlled release of APIs including biomolecules and vaccines. However, one of the key challenges of spray-dried formulations especially with poly(lactic-co-glycolic acid) (PLGA)-based controlled-release injectables is burst release, where a significant fraction of the API is released prematurely within a short period of time following administration, leading to detrimental impact on the performance and quality of end products. This study uses a model API, bovine serum albumin (BSA) protein, to identify the sources of burst release that may affect the kinetics an

SUBMITTER: Michaelides K 

PROVIDER: S-EPMC11615953 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature