AN INTEGRATIVE NETWORK-BASED MEDIATION MODEL (NMM) TO ESTIMATE MULTIPLE GENETIC EFFECTS ON OUTCOMES MEDIATED BY FUNCTIONAL CONNECTIVITY.

ABSTRACT: Functional connectivity of the brain, characterized by interconnected neural circuits across functional networks, is a cutting-edge feature in neuroimaging. It has the potential to mediate the effect of genetic variants on behavioral outcomes or diseases. Existing mediation analysis methods can evaluate the impact of genetics and brain structurefunction on cognitive behavior or disorders, but they tend to be limited to single genetic variants or univariate mediators, without considering cumulative genetic effects and the complex matrix and group and network structures of functional connectivity. To address this gap, the paper presents an integrative network-based mediation model (NMM) that estimates the effect of multiple genetic variants on behavioral outcomes or diseases mediated by func

SUBMITTER: Dai W 

PROVIDER: S-EPMC11616023 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature