Metabolic pathways from the gut metatranscriptome are associated with COPD and respiratory function in lung cancer patients.

ABSTRACT:

Introduction

Changes in the human gut microbiome have been linked to various chronic diseases, including chronic obstructive pulmonary disease (COPD). While substantial knowledge is available on the genomic features of fecal communities, little is known about the microbiome's transcriptional activity. Here, we analyzed the metatranscriptomic (MTR) abundance of MetaCyc pathways, SuperPathways, and protein domain families (PFAM) represented by the gut microbiome in a cohort of non-small cell lung cancer (NSCLC) patients with- or without COPD comorbidity.

Methods

Fecal samples of 40 NSCLC patients with- or without COPD comorbidity were collected at the time of diagnosis. Data was preprocessed using the Metaphlan3/Humann3 pipeline and BioCyc^© to identify metabolic Sup

SUBMITTER: Dora D 

PROVIDER: S-EPMC11616033 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature