Use of Population-Based Compartmental Modeling and Retinol Isotope Dilution to Study Vitamin A Kinetics and Total Body Stores among Ghanaian Women of Reproductive Age.

ABSTRACT:

Background

Limited data are available on vitamin A kinetics and total body stores (TBS) in women. Such information can be obtained using compartmental modeling and retinol isotope dilution (RID).

Objectives

Objectives were to apply population-based ("super-subject") modeling to determine retinol kinetics in nonpregnant Ghanaian women of reproductive age and to use RID to predict TBS in the group and its individuals.

Methods

Women (n = 89) ingested a dose of [²H₆]retinyl acetate and blood samples (3/woman) were collected from 6 h to 91 d, with all participants sampled at 14 d, about half at either 21 or 28 d, and each at one other time. Composite data (plasma retinol fraction of dose; FD_p) were analyzed using Simulation, Analysis

SUBMITTER: Green MH 

PROVIDER: S-EPMC11616041 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature