Older is order: entropy reduction in cortical spontaneous activity marks healthy aging.

ABSTRACT:

Background

Entropy trajectories remain unclear for the aging process of human brain system due to the lacking of longitudinal neuroimaging resource.

Results

We used open data from an accelerated longitudinal cohort (PREVENT-AD) that included 24 healthy aging participants followed by 4 years with 5 visits per participant to establish cortical entropy aging curves and distinguish with the effects of age and cohort. This reveals that global cortical entropy decreased with aging, while a significant cohort effect was detectable that people who were born earlier showed higher cortical entropy. Such entropy reductions were also evident for large-scale cortical networks, although with different rates of reduction for different networks. Specifically, the primary and intermediate ne

SUBMITTER: Chang D 

PROVIDER: S-EPMC11616130 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature