Construction of the porcine genome mobile element variations and investigation of its role in population diversity and gene expression.

ABSTRACT:

Background

Mobile element variants (MEVs) have a significant and complex impact on genomic diversity and phenotypic traits. However, the quantity, distribution, and relationship with gene expression and complex traits of MEVs in the pig genome remain poorly understood.

Results

We constructed the most comprehensive porcine MEV library based on high-depth whole genome sequencing (WGS) data from 747 pigs across 59 breeds worldwide. This database identified a total of 147,993 polymorphic MEVs, including 121,099 short interspersed nuclear elements (SINEs), 26,053 long interspersed nuclear elements (LINEs), 802 long terminal repeats (LTRs), and 39 other transposons, among which 54% are newly discovered. We found that MEVs are unevenly distributed across the genome and are strongly

SUBMITTER: Hu J 

PROVIDER: S-EPMC11616153 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature