Multimodal genome-wide survey of progressing and non-progressing breast ductal carcinoma in-situ.

ABSTRACT:

Background

Ductal carcinoma in-situ (DCIS) is a pre-invasive form of invasive breast cancer (IBC). Due to improved breast cancer screening, it now accounts for ~ 25% of all breast cancers. While the treatment success rates are over 90%, this comes at the cost of considerable morbidity, considering that the majority of DCIS never become invasive and our understanding of the molecular changes occurring in DCIS that predispose to invasive disease is limited. The aim of this study is to characterize molecular changes that occur in DCIS, with the goal of improving DCIS risk stratification.

Methods

We identified and obtained a total of 197 breast tissue samples from 5 institutions (93 DCIS progressors, 93 DCIS non-progressors, and 11 adjacent normal breast tissues) that had at lea

SUBMITTER: Debeljak M 

PROVIDER: S-EPMC11616160 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature