Early introduction of IL-10 weakens BCG revaccination's protection by suppressing CD4⁺Th1 cell responses.

ABSTRACT:

Background

The Bacillus Calmette-Guérin (BCG) vaccine, currently the sole authorized vaccine against tuberculosis (TB), demonstrates limited effectiveness in safeguarding adolescents and adults from active TB, even when administered as a booster with either BCG itself or heterologous vaccine candidates. To effectively control the persistent epidemic of adult TB, it is imperative to investigate the mechanisms responsible for the suboptimal efficacy of the BCG prime-boosting strategy against primary Mycobacterium tuberculosis (M.tb) infection.

Methods

C57BL/6J mice were immunized with the BCG vaccine either once or twice, followed by analysis of lung tissue to assess changes in cytokine levels. Additionally, varying intervals between vaccinations and detection times were exami

SUBMITTER: Lei Q 

PROVIDER: S-EPMC11616166 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature