Single-cell view and a novel protective macrophage subset in perivascular adipose tissue in T2DM.

ABSTRACT:

Background

Vasculopathy underlies diabetic complications, with perivascular adipose tissue (PVAT) playing crucial roles in its development. However, the changes in the cellular composition and function of PVAT, including the specific cell subsets and mechanisms implicated in type 2 diabetes mellitus (T2DM) vasculopathy, remain unclear.

Methods

To address the above issues, we performed single-cell RNA sequencing on the stromal vascular fraction (SVF) of PVAT from normal and T2DM rats. Then, various bioinformatics tools and functional experiments were used to investigate the characteristic changes in the cellular profile of diabetic PVAT SVF, their implications, and the underlying mechanisms.

Results

Our study reveals the single-cell landscape of the SVF of PVAT, demons

SUBMITTER: Li J 

PROVIDER: S-EPMC11616190 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature