Decellularized Biohybrid Nerve Promotes Motor Axon Projections.

ABSTRACT: Developing nerve grafts with intact mesostructures, superior conductivity, minimal immunogenicity, and improved tissue integration is essential for the treatment and restoration of neurological dysfunctions. A key factor is promoting directed axon growth into the grafts. To achieve this, biohybrid nerves are developed using decellularized rat sciatic nerve modified by in situ polymerization of poly(3,4-ethylenedioxythiophene) (PEDOT). Nine biohybrid nerves are compared with varying polymerization conditions and cycles, selecting the best candidate through material characterization. These results show that a 1:1 ratio of FeCl₃ oxidant to ethylenedioxythiophene (EDOT) monomer, cycled twice, provides superior conductivity (>0.2 mS cm^-1), mechanical alignment, intact meso

SUBMITTER: Mehta AS 

PROVIDER: S-EPMC11616264 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature