Genomic and clinical characterization of pediatric lymphoepithelioma-like carcinoma.

ABSTRACT:

Background

Pediatric lymphoepithelioma-like carcinoma (pLELC) is a rare neoplasm with unclear prognosis, genome, and tumor microenvironment. Our study aims to elucidate its genomic and clinical characteristics.

Methods

Forty-one pLELC patients were enrolled at Sun Yat-sen University Cancer Center from 2012 to 2023. Kaplan-Meier analysis was utilized to estimate progression-free survival (PFS) and overall survival (OS). Baseline plasma protein levels from 16 patients and 9 health controls were analyzed using a Olink proteomic platform and whole exon sequence (WES) was performed on 11 tumor samples from 10 pediatric patients. Immunohistochemistry (IHC) for PD-L1was performed, and the infiltration of CD4⁺ or CD8⁺ T cells was evaluated.

Results

Patie

SUBMITTER: Que Y 

PROVIDER: S-EPMC11616302 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature