Revisiting mutational resistance to ampicillin and cefotaxime in Haemophilus influenzae.

ABSTRACT:

Background

Haemophilus influenzae is an opportunistic bacterial pathogen that can cause severe respiratory tract and invasive infections. The emergence of β-lactamase-negative ampicillin-resistant (BLNAR) strains and unclear correlations between genotypic (i.e., gBLNAR) and phenotypic resistance are challenging empirical treatments and patient management. Thus, we sought to revisit molecular resistance mechanisms and to identify new resistance determinants of H. influenzae.

Methods

We performed a systematic meta-analysis of H. influenzae isolates (n = 291) to quantify the association of phenotypic ampicillin and cefotaxime resistance with previously defined resistance groups, i.e., specific substitution patterns of the penicillin binding protein PBP3, encoded by ftsI. Using

SUBMITTER: Diricks M 

PROVIDER: S-EPMC11616347 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature