Efficacy of melatonin for prolonged disorders of consciousness: a double-blind, randomized clinical trial.

ABSTRACT:

Background

Sleep is essential for the recovery of patients with disorders of consciousness (DoC). However, few approaches targeting sleep were applied. Melatonin has been shown to enhance sleep efficiency with virtually no side effects. This study explored melatonin's benefits for patients with prolonged DoC, as well as the underlying mechanisms involved.

Methods

A cohort of 46 patients with prolonged DoC were randomly assigned to either the melatonin treatment group or the placebo group. Assessments were conducted using the Coma Recovery Scale-Revised (CRS-R), electroencephalography (EEG), and polysomnography (PSG) before and after the intervention, with follow-up CRS-R evaluations performed 6 months post-treatment.

Results

Compared to the placebo, melatonin demonstr

SUBMITTER: Wen X 

PROVIDER: S-EPMC11616348 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature