Targeting autophagy in HCC treatment: exploiting the CD147 internalization pathway.

ABSTRACT:

Background/aims

Chemotherapy resistance in liver cancer is a major clinical issue, with CD147 playing a vital role in this process. However, the specific mechanisms underlying these processes remain largely unknown. This study investigates how CD147 internalization leads to cytoprotective autophagy, contributing to chemotherapy resistance in hepatocellular carcinoma (HCC).

Methods

Utilizing bioinformatics methods for KEGG pathways enrichment and screening key molecules associated with chemotherapy resistance through analyses of GEO and TCGA databases. An overexpression/knockdown system was used to study how CD147 internalization leads to autophagy in vitro and in vivo. The process was observed using microscopes, and molecular interactions and autophagy flux were analyzed. An

SUBMITTER: Qian M 

PROVIDER: S-EPMC11616386 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature