Changes in senescence markers after a weight loss intervention in older adults with obesity.

ABSTRACT:

Background

Understanding how weight loss interventions in older adults with obesity impact aging biology can lay the foundation for targeted, 'geroscience-based' interventions. This study examines the association between changes in the senescence-associated secretory phenotypes (SASP) and changes in function in response to a weight loss intervention.

Methods

We conducted a post-hoc biomarker analysis on adults aged ≥ 65 years with body mass index [BMI] ≥30 kg/m² enrolled in a six-month, non-randomized telemedicine-delivered weight loss intervention. We assessed 16 SASP cytokines using serum samples collected pre-and post-intervention. Clinical outcomes include anthropometric and physical function measurements. A weight loss responder was defined as a loss of ≥5 %

SUBMITTER: Lynch DH 

PROVIDER: S-EPMC11616393 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature