Association of urinary eosinophilic protein X at age 3 years and subsequent persistence of wheezing and asthma diagnosis in adolescence.

ABSTRACT:

Background

Wheezing is common in early life, but most children stop wheezing by school age. However, the prediction of course of wheezing through childhood is difficult.

Objective

To investigate whether urinary EPX (a marker of eosinophil activation) in children at age 3 years may be useful for the prediction of wheeze persistence and future asthma diagnosis.

Methods

U-EPX was measured at age 3 years (radioimmunoassay) in 906 participants in the population-based birth cohort. Children attended follow-ups to age 16 years. We investigate the discriminative ability of u-EPX and other factors in predicting asthma diagnosis at age 16 using receiver operating characteristic [ROC] curves.

Results

Of 613 children with follow-up information at age 16, 511 had data on u-

SUBMITTER: Oloyede IP 

PROVIDER: S-EPMC11616470 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature