Duration of food protein-induced allergic proctocolitis (FPIAP) and the role of intestinal microbiota.

ABSTRACT:

Background

Food protein-induced allergic proctocolitis (FPIAP) is the leading cause of rectal bleeding in infants. Tolerance is presumed to develop until the first year of age, although natural history studies are scarce, making the determination of the ideal duration for any intervention, challenging. Intestinal microbiota (IM) is crucial in food allergy development; however, data for FPIAP remain limited. This study aimed to assess FPIAP remission after 3 months of milk avoidance and its correlation with IM longitudinal changes.

Methods

A prospective observational study of infants aged ≤6 months with a diagnosis of FPIAP. After 3 months of management according to a clinical algorithm, infants were subjected to a milk challenge using either a cow (CM) or a goat (GM) milk fo

SUBMITTER: Vallianatou GN 

PROVIDER: S-EPMC11616471 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature