Risk of all-cause mortality in patients with knee osteoarthritis: A systematic review and meta-analysis of cohort studies.

ABSTRACT:

Objective

This systematic review and meta-analysis aimed to evaluate the risk of all-cause mortality in patients with knee osteoarthritis (OA).

Design

Comprehensive searches were conducted in PubMed, Embase, and the Cochrane Library on September 01, 2024. The review included cohort studies reporting risk estimates of all-cause mortality in knee OA patients compared to those without knee OA. Using a random-effects model, the pooled hazard ratios (HRs) were calculated. Subgroup analyses were performed according to the classification of knee OA, including radiographic knee OA only, symptomatic knee OA only, and radiographic and symptomatic knee OA.

Results

A total of 15 cohort studies involving 1,023,799 participants were included in the systematic review, with 14 studie

SUBMITTER: Kao PE 

PROVIDER: S-EPMC11616512 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature