Identification of PANoptosis-based signature for predicting the prognosis and immunotherapy response in AML.

ABSTRACT:

Background

In recent years, the incidence of acute myeloid leukemia (AML) has increased rapidly with a suboptimal prognosis. In AML, cell death is independent of tumorigenesis, tumor invasion, and drug resistance. PANoptosis is a newly discovered form of cell death that combines pyroptosis, apoptosis, and necroptosis. However, no studies have explored the role of PANoptosis-based signatures in AML.

Methods

We screened for PANoptosis-related genes and established a PANoptosis-risk signature using the least absolute shrinkage and selection operator (LASSO) and Cox regression analysis. We combined TCGA, bulk RNA sequencing, and single-cell sequencing to investigate the correlation between candidate genes and the AML tumor microenvironment.

Results

The PANoptosis risk sig

SUBMITTER: Zhang L 

PROVIDER: S-EPMC11616514 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature