NOS3 regulates angiogenic potential of human induced pluripotent stem cell-derived endothelial cells.

ABSTRACT: Incorporation of blood capillaries in engineered tissues and their functional connection to host blood vessels is essential for success in engineering vascularized tissues, a process which involves spatial patterning of endothelial cells (ECs) to form functional and integrated vascular networks. Different types of ECs have been employed for vascular network formation and each source offers advantages and disadvantages. While ECs derived from induced pluripotent stem cells (iPSC-ECs) offer advantages over primary ECs in that they can be generated in large quantities for autologous applications, their suitability for disease modelling and cell replacement therapies is not well-explored. The present study compares the angiogenic capacity of iPSC-ECs and primary ECs (cardiac microvascular ECs

SUBMITTER: Kong AM 

PROVIDER: S-EPMC11616527 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature