Collagen signature adds prognostically significant information to staging for breast cancer.

ABSTRACT:

Background

Tumor-associated collagen signature (TACS) is an independent prognostic factor for breast cancer. However, it is unclear whether the complete collagen signature, including TACS, the TACS-based collagen microscopic features (TCMF1), and the TACS-based nuclear features (TCMF2), can provide additional prognostic information for the current tumor-node-metastasis (TNM) staging system.

Patients and methods

We included 941 patients with breast cancer from three cohorts: the training (n = 355), internal (n = 334), and external validation cohorts (n = 252). TACS and TCMF1 were obtained by multiphoton microscopy (MPM). TCMF2 was extracted on the hematoxylin and eosin images colocated with MPM images. They were linearly combined to establish a complete collagen signature sco

SUBMITTER: Li Z 

PROVIDER: S-EPMC11616558 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature